1891 Beach Blvd., Suite 200
Jacksonville Beach, FL 32250

Phone: 904.249.3743
Fax: 904.249.2047

Clinic Hours:

Mon – Thurs: 7:30 a.m. – 5:00 p.m.
Frid: 7:30 a.m. – 12:00 p.m.

Women’s Hormone Lifecycles: Pre-Menopause

What is Pre-Menopause

Many women (and most medical professionals) are unaware that hormone imbalances typically begin during a woman’s early 30s. Often, symptoms of Pre-Menopause, or pre-menopause, are misdiagnosed and mistreated. Progesterone, sometimes called the feel-good hormone, is usually the first to decline. As progesterone begins to decline and estrogen becomes more dominant, symptoms such as PMS, breast swelling, irregular periods, fatigue, fluid retention, uterine fibroids, fibrocystic disease, reduced libido, and migraine headaches can occur. From their mid-thirties on, ALL women can be considered estrogen-dominant

What is Estrogen Dominance? 

Estrogen dominance does not necessarily mean that the body produces too much estrogen (although that can happen too); it means that your body’s estrogen production is not in balance with your progesterone production. Estrogen dominance occurs when your ovaries continue to produce the same amount (or sometimes higher) of estrogen while producing less and less progesterone. All women in their thirties experience this change at varying levels — a natural process of aging ovaries. 

To understand estrogen dominance, you must also understand the role of progesterone. Estrogen and progesterone operate like sides of a seesaw, shifting up and down during a woman’s monthly cycle. When progesterone gets low, that side of the seesaw hits the ground, and this effect causes negative symptoms to arise: poor sleep, fatigue, anxiety, heavy periods, low libido or sex drive, weight gain, uterine fibroids, irritability, and even rage. When the progesterone side of the seesaw gets stuck on the ground, the estrogen side is elevated relative to progesterone. It’s not necessarily that your estrogen is high — it’s that your progesterone level drops so low that estrogen effectively dominates. 

Other Factors that Can Cause Hormone Imbalance 

A shift in hormones produced by the adrenal glands also begins in Pre-Menopause. DHEA levels that peaked in your twenties slowly and steadily decline, dropping approximately 10 percent every decade. Some medical studies correlate the decline in DHEA production with many degenerative changes in women and men, such as heart disease, cancer, and osteoporosis. Birth control pills can also create a relative testosterone deficiency. Taking birth control pills causes your levels of the hormone-carrying protein sex hormone binding globulin (SHGB) to rise. These higher levels of SHGB, in turn, bind up the levels of free testosterone circulating in your blood, resulting in a condition of relative testosterone deficiency. Although your testosterone levels may (or may not) appear within normal limits on a blood test, the amount available for use by your tissues is far lower than what is needed. The result for you: symptoms of low testosterone, which include low libido, low energy, poor memory, fatigue, depression, and apathy. 

How Can I Restore Hormone Balance During Pre-Menopause? 

Dr. Randolph has created specific guidelines to help you determine your individual supplementation needs depending on your age, menstrual history, symptoms, and hormone test results. Recommended pre-menopause supplements are based on specific criteria, including:

  • Age range
  • Life cycle
  • Associated hormone level shifts
  • The resulting type of imbalance/medical condition
  • Common symptoms.

All hormonal supplements are bioidentical formulations that duplicate the natural physiology of hormones in the body. Ingredients, as listed, are derived from natural and/or plant-based substances. 

What Can I Expect From Pre-Menopause Treatment? 

The answer is simple: relief from unwanted symptoms! You should expect:

  • Improved libido
  • Moods
  • Memory
  • Sleep
  • Renewed strength and energy
  • More efficient weight loss

When or if symptoms persist, adrenal support (to manage stress), additional bioidentical hormone supplementation, and/or a compounded formulation may also be required.


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